In mouse auditory cortex, callosal projections from the contralateral hemispher…

In mouse auditory cortex, callosal projections from the contralateral hemisphere produce opposite effects on the two main L5 pyramidal output classes: they suppress firing of cortico-cortical (CCort) IT pyramidal neurons (via fast-spiking parvalbumin interneurons) while facilitating firing of cortico-collicular (CCol) PT pyramidal neurons, defining two divergent interhemispheric microcircuits within L5.

{
  "n": 0,
  "doi": "10.1523/jneurosci.5049-14.2015",
  "claim": "In mouse auditory cortex, callosal projections from the contralateral hemisphere produce opposite effects on the two main L5 pyramidal output classes: they suppress firing of cortico-cortical (CCort) IT pyramidal neurons (via fast-spiking parvalbumin interneurons) while facilitating firing of cortico-collicular (CCol) PT pyramidal neurons, defining two divergent interhemispheric microcircuits within L5.",
  "cite_key": "Rock2015",
  "evidence": "ChR2-assisted optogenetic activation of contralateral callosal axons with whole-cell recording of retrogradely labeled L5 CCort (IT) and CCol (PT) neurons in mouse auditory cortex slices.",
  "effect_size": "qualitative — opposite-sign callosal modulation of two L5 projection classes via FS-PV gating",
  "text_access": "abstract_only",
  "study_system": "mouse auditory cortex L5 IT (CCort) and PT (CCol) pyramidal neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons. This difference is mechanistically explained by callosal activation of fast-spiking parvalbumin-expressing interneurons (FS-PARV), which provide selective inhibition to CCort pyramidal neurons",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1093/cercor/bhx025"
  ],
  "effect_size_source_sentence": "callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons"
}

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]

callosal projections suppress the activity of CCort pyramidal neurons, but facilitate firing of CCol pyramidal neurons. This difference is mechanistically explained by callosal activation of fast-spiking parvalbumin-expressing interneurons (FS-PARV), which provide selective inhibition to CCort pyramidal neurons

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