Version history

{
  "scope": "human, middle temporal gyrus (adult); compared to mouse cortex literature",
  "claim_text": "Human middle temporal gyrus contains roughly equal proportions of MGE-derived (44% LHX6+) and CGE-derived (50% ADARB2+) cortical interneurons by single-nucleus RNA-seq, in stark contrast to mouse cortex where MGE-derived interneurons constitute ~70% and CGE-derived ~30% — establishing a major species-specific shift toward CGE-lineage interneuron expansion in primates/humans.",
  "raw_fields": {
    "n": null,
    "doi": "10.1038/s41586-019-1506-7",
    "claim": "Human middle temporal gyrus contains roughly equal proportions of MGE-derived (44% LHX6+) and CGE-derived (50% ADARB2+) cortical interneurons by single-nucleus RNA-seq, in stark contrast to mouse cortex where MGE-derived interneurons constitute ~70% and CGE-derived ~30% — establishing a major species-specific shift toward CGE-lineage interneuron expansion in primates/humans.",
    "title": null,
    "cite_key": "Hodge2019",
    "evidence": "Single-nucleus RNA-seq of ~16,000 nuclei from layer-dissected human middle temporal gyrus; clustered into 75 cell types including 45 GABAergic; LHX6 vs ADARB2 expression assigned MGE vs CGE lineage.",
    "effect_size": "Human: 44% MGE / 50% CGE; Mouse: ~70% MGE / ~30% CGE",
    "figure_data": [
      {
        "type": "lineage_fraction",
        "unit": "percent",
        "value": 44,
        "metric": "% LHX6+ (MGE-derived) interneurons in human MTG",
        "source": "Hodge 2019 snRNA-seq",
        "context": "vs ~70% in mouse cortex"
      },
      {
        "type": "lineage_fraction",
        "unit": "percent",
        "value": 50,
        "metric": "% ADARB2+ (CGE-derived) interneurons in human MTG",
        "source": "Hodge 2019 snRNA-seq",
        "context": "vs ~30% in mouse cortex"
      }
    ],
    "text_access": "fulltext",
    "study_system": "human, middle temporal gyrus (adult); compared to mouse cortex literature",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "primary",
    "_source_cluster_index": 99,
    "claim_source_sentence": "Human MTG had similar proportions of MGE (44% LHX6+ nuclei) and CGE (50% ADARB2+ nuclei) interneurons based on snRNA-seq data. In contrast, prior studies report ~70% MGE versus ~30% CGE interneurons in mouse cortex 38 , 42 .",
    "replication_evidence_dois": [
      "10.1126/science.aav2522",
      "10.1038/nature25999"
    ],
    "effect_size_source_sentence": "Human MTG had similar proportions of MGE (44% LHX6+ nuclei) and CGE (50% ADARB2+ nuclei) interneurons based on snRNA-seq data."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Human: 44% MGE / 50% CGE; Mouse: ~70% MGE / ~30% CGE",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-pm-31435019"
  ],
  "source_span": "Human MTG had similar proportions of MGE (44% LHX6+ nuclei) and CGE (50% ADARB2+ nuclei) interneurons based on snRNA-seq data. In contrast, prior studies report ~70% MGE versus ~30% CGE interneurons in mouse cortex 38 , 42 .",
  "study_system": "human, middle temporal gyrus (adult); compared to mouse cortex literature",
  "evidence_refs": [
    {
      "ref": "paper:paper-pm-31435019"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Single-nucleus RNA-seq of ~16,000 nuclei from layer-dissected human middle temporal gyrus; clustered into 75 cell types including 45 GABAergic; LHX6 vs ADARB2 expression assigned MGE vs CGE lineage.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "primary",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}