Human middle temporal gyrus contains roughly equal proportions of MGE-derived (…

Human middle temporal gyrus contains roughly equal proportions of MGE-derived (44% LHX6+) and CGE-derived (50% ADARB2+) cortical interneurons by single-nucleus RNA-seq, in stark contrast to mouse cortex where MGE-derived interneurons constitute ~70% and CGE-derived ~30% — establishing a major species-specific shift toward CGE-lineage interneuron expansion in primates/humans.

{
  "n": null,
  "doi": "10.1038/s41586-019-1506-7",
  "claim": "Human middle temporal gyrus contains roughly equal proportions of MGE-derived (44% LHX6+) and CGE-derived (50% ADARB2+) cortical interneurons by single-nucleus RNA-seq, in stark contrast to mouse cortex where MGE-derived interneurons constitute ~70% and CGE-derived ~30% — establishing a major species-specific shift toward CGE-lineage interneuron expansion in primates/humans.",
  "title": null,
  "cite_key": "Hodge2019",
  "evidence": "Single-nucleus RNA-seq of ~16,000 nuclei from layer-dissected human middle temporal gyrus; clustered into 75 cell types including 45 GABAergic; LHX6 vs ADARB2 expression assigned MGE vs CGE lineage.",
  "effect_size": "Human: 44% MGE / 50% CGE; Mouse: ~70% MGE / ~30% CGE",
  "figure_data": [
    {
      "type": "lineage_fraction",
      "unit": "percent",
      "value": 44,
      "metric": "% LHX6+ (MGE-derived) interneurons in human MTG",
      "source": "Hodge 2019 snRNA-seq",
      "context": "vs ~70% in mouse cortex"
    },
    {
      "type": "lineage_fraction",
      "unit": "percent",
      "value": 50,
      "metric": "% ADARB2+ (CGE-derived) interneurons in human MTG",
      "source": "Hodge 2019 snRNA-seq",
      "context": "vs ~30% in mouse cortex"
    }
  ],
  "text_access": "fulltext",
  "study_system": "human, middle temporal gyrus (adult); compared to mouse cortex literature",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 99,
  "claim_source_sentence": "Human MTG had similar proportions of MGE (44% LHX6+ nuclei) and CGE (50% ADARB2+ nuclei) interneurons based on snRNA-seq data. In contrast, prior studies report ~70% MGE versus ~30% CGE interneurons in mouse cortex 38 , 42 .",
  "replication_evidence_dois": [
    "10.1126/science.aav2522",
    "10.1038/nature25999"
  ],
  "effect_size_source_sentence": "Human MTG had similar proportions of MGE (44% LHX6+ nuclei) and CGE (50% ADARB2+ nuclei) interneurons based on snRNA-seq data."
}

[
  "paper:paper-pm-31435019"
]

[
  {
    "ref": "paper:paper-pm-31435019"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}