Wide-field calcium imaging across mouse dorsal cortex during a visual change-de…

Wide-field calcium imaging across mouse dorsal cortex during a visual change-detection task showed that covert antecedents of choice begin with confined modulation of visual cortex followed by sustained recruitment of secondary and primary motor cortex; recruitment of motor cortex by sensory evidence depended on temporal expectation — a quantitative cortex-wide trajectory of perceptual decision-making.

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  "doi": "10.1016/j.neuron.2021.03.031",
  "claim": "Wide-field calcium imaging across mouse dorsal cortex during a visual change-detection task showed that covert antecedents of choice begin with confined modulation of visual cortex followed by sustained recruitment of secondary and primary motor cortex; recruitment of motor cortex by sensory evidence depended on temporal expectation — a quantitative cortex-wide trajectory of perceptual decision-making.",
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  "evidence": "Wide-field dorsal-cortex calcium imaging during decision-making; dissociation of execution vs covert antecedent signals; expectation-dependent motor-cortex recruitment.",
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Although signals related to execution of choice were widespread, fluctuations in sensory evidence in the absence of overt motor responses triggered a confined activity cascade, beginning with transient modulation of visual cortex and followed by sustained recruitment of the secondary and primary motor cortex.

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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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