Autophagy regulates PVALB (parvalbumin) interneuron excitability and memory — M…

{
  "n": 0,
  "doi": "10.1080/15548627.2025.2597463",
  "claim": "Autophagy regulates PVALB (parvalbumin) interneuron excitability and memory — Macroautophagy/autophagy was previously shown to play a critical role in the hippocampus for memory formation, with age-related autophagy deficits being further",
  "title": null,
  "cite_key": "Chalatsi2026",
  "evidence": "Reported in Autophagy (2026); from Body of abstract.",
  "effect_size": "5",
  "text_access": "abstract_only",
  "study_system": "mouse",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 352,
  "claim_source_sentence": "Macroautophagy/autophagy was previously shown to play a critical role in the hippocampus for memory formation, with age-related autophagy deficits being further linked to cognitive decline.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Taken together, these findings identify PVALB interneurons as key cellular substrates of autophagy in the context of learning and memory.Abbreviation: ATG5: autophagy related 5; BNIP3: BCL2/adenovirus E1B interacting protein 3; BNIP3L: BCL2/adenovirus E1B interacting protein 3-like; CA1: cornu ammonis 1; CALCOCO1: calcium binding and coiled coil domain 1; ER: endoplasmic reticulum; GABA: gamma-aminobutyric acid; GRIA/AMPAR: glutamate receptor, ionotropic, AMPA; GRIN2A/NR2A/GluN2A: glutamate receptor, ionotropic, NMDA2A (epsilon 1); PRKN: parkin RBR E3 ubiquitin protein ligase; PC: pyramidal cells; PJ: Purkinje; PVALB: parvalbumin; RTN3: reticulon 3; SQSTM1/p62: sequestosome 1."
}

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