Version history

{
  "scope": "6-OHDA-lesioned rat model of Parkinson's disease, freely moving",
  "claim_text": "Cortical-theta-phase-locked closed-loop STN stimulation worsens parkinsonian behavior and increases cortical beta amplitude, opposite to the effect of conventional high-frequency open-loop DBS.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.brs.2017.10.004",
    "claim": "Cortical-theta-phase-locked closed-loop STN stimulation worsens parkinsonian behavior and increases cortical beta amplitude, opposite to the effect of conventional high-frequency open-loop DBS.",
    "cite_key": "Cordon2018",
    "evidence": "6-OHDA-lesioned and control rats with chronic STN electrodes; cortical-LFP-triggered phase-locked stimulation compared with classical 130 Hz HFS.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "6-OHDA-lesioned rat model of Parkinson's disease, freely moving",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Motor improvement during open-loop, high-frequency DBS was accompanied by a reduction in the amount of cortical beta oscillations while akinetic and disturbed behavior during close-loop stimulation coincided with an increase in the amplitude of beta activity.",
    "replication_evidence_dois": [
      "10.1038/s41598-026-37066-0",
      "10.1016/j.bpsgos.2026.100712"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-08e3f88e6301"
  ],
  "source_span": "Motor improvement during open-loop, high-frequency DBS was accompanied by a reduction in the amount of cortical beta oscillations while akinetic and disturbed behavior during close-loop stimulation coincided with an increase in the amplitude of beta activity.",
  "study_system": "6-OHDA-lesioned rat model of Parkinson's disease, freely moving",
  "evidence_refs": [
    {
      "ref": "paper:paper-08e3f88e6301"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "6-OHDA-lesioned and control rats with chronic STN electrodes; cortical-LFP-triggered phase-locked stimulation compared with classical 130 Hz HFS.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}