- raw_fields
{
"n": 0,
"doi": "10.1016/j.brs.2017.10.004",
"claim": "Cortical-theta-phase-locked closed-loop STN stimulation worsens parkinsonian behavior and increases cortical beta amplitude, opposite to the effect of conventional high-frequency open-loop DBS.",
"cite_key": "Cordon2018",
"evidence": "6-OHDA-lesioned and control rats with chronic STN electrodes; cortical-LFP-triggered phase-locked stimulation compared with classical 130 Hz HFS.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "6-OHDA-lesioned rat model of Parkinson's disease, freely moving",
"source_cluster_id": "cluster_13",
"replication_status": "independently_replicated",
"claim_source_sentence": "Motor improvement during open-loop, high-frequency DBS was accompanied by a reduction in the amount of cortical beta oscillations while akinetic and disturbed behavior during close-loop stimulation coincided with an increase in the amplitude of beta activity.",
"replication_evidence_dois": [
"10.1038/s41598-026-37066-0",
"10.1016/j.bpsgos.2026.100712"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-08e3f88e6301"
]
- source_span
Motor improvement during open-loop, high-frequency DBS was accompanied by a reduction in the amount of cortical beta oscillations while akinetic and disturbed behavior during close-loop stimulation coincided with an increase in the amplitude of beta activity.
- evidence_refs
[
{
"ref": "paper:paper-08e3f88e6301"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}