Details

scope
mouse isocortex and hippocampal formation
claim_text
The mouse isocortex and hippocampal formation contain a Pvalb subclass that divides into 3 supertypes, including a hippocampus-specific Pvalb chandelier cell cluster with unique markers Ntf3 and Sntb1.
section_id
section_02_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
effect_size
~1.3 million cells profiled; Pvalb divided into 3 supertypes
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-02
source_kind
review_finding
source_path
evidence/section_02_evidence_package.json
source_span
the Sst and Pvalb subclasses are divided into 11 and 3 supertypes, respectively. We also identified a HIP-specific Pvalb chandelier cell cluster #122 with unique markers Ntf3 and Sntb1.
study_system
mouse isocortex and hippocampal formation
section_title
Molecular Identity and Transcriptomic Taxonomy
evidence_summary
Profiled ~1.3 million cells covering adult mouse isocortex and HPF using scRNA-seq to create comprehensive transcriptomic taxonomy.
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-02
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_02_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
raw_fields
{
  "n": 1300000,
  "doi": "10.1016/j.cell.2021.04.021",
  "claim": "The mouse isocortex and hippocampal formation contain a Pvalb subclass that divides into 3 supertypes, including a hippocampus-specific Pvalb chandelier cell cluster with unique markers Ntf3 and Sntb1.",
  "evidence": "Profiled ~1.3 million cells covering adult mouse isocortex and HPF using scRNA-seq to create comprehensive transcriptomic taxonomy.",
  "effect_size": "~1.3 million cells profiled; Pvalb divided into 3 supertypes",
  "text_access": "fulltext",
  "study_system": "mouse isocortex and hippocampal formation",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "the Sst and Pvalb subclasses are divided into 11 and 3 supertypes, respectively. We also identified a HIP-specific Pvalb chandelier cell cluster #122 with unique markers Ntf3 and Sntb1.",
  "replication_evidence_dois": [
    "10.1038/s41586-023-06812-z"
  ],
  "effect_size_source_sentence": "We profiled ~1.3 million cells covering the entire adult mouse isocortex and HPF and derived a transcriptomic cell type taxonomy."
}
source_refs
[
  "paper:paper-4dfe44516146"
]
evidence_refs
[
  {
    "ref": "paper:paper-4dfe44516146"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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