- claim_text
In hippocampal CA1, VIP+/calretinin+ interneuron-specific type 3 (IS3) cells preferentially innervate oriens-lacunosum moleculare (OLM) interneurons through dendritic synapses with small unitary IPSCs (low Pr) that summate during high-frequency firing; VIP+ basket cells (not IS3) provide asynchronous perisomatic inhibition to pyramidal neurons but do not contact O/A interneurons — establishing distinct VIP subclasses with non-overlapping post-synaptic targeting.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.3813-13.2014",
"claim": "In hippocampal CA1, VIP+/calretinin+ interneuron-specific type 3 (IS3) cells preferentially innervate oriens-lacunosum moleculare (OLM) interneurons through dendritic synapses with small unitary IPSCs (low Pr) that summate during high-frequency firing; VIP+ basket cells (not IS3) provide asynchronous perisomatic inhibition to pyramidal neurons but do not contact O/A interneurons — establishing distinct VIP subclasses with non-overlapping post-synaptic targeting.",
"title": null,
"cite_key": "Tyan2014",
"evidence": "Dual simultaneous paired patch-clamp recordings + targeted optogenetic stimulation in acute mouse hippocampal slices.",
"effect_size": "IS3→OLM synapses: small amplitude, low Pr, efficient summation at high frequencies.",
"text_access": "fulltext",
"study_system": "mouse hippocampus CA1; ex vivo paired-patch + optogenetics",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replicates",
"_source_cluster_index": 39,
"claim_source_sentence": "We found that type 3 IS (IS3) cells that coexpress the vasoactive intestinal polypeptide (VIP) and calretinin contact several distinct types of interneurons within the hippocampal CA1 stratum oriens/alveus (O/A), with preferential innervation of oriens-lacunosum moleculare cells (OLMs) through dendritic synapses. In contrast, VIP-positive basket cells provided perisomatic inhibition to CA1 pyramidal neurons with the asynchronous GABA release and were not connected with O/A interneurons.",
"replication_evidence_dois": [
"10.1016/j.neuron.2019.01.009",
"10.1038/s41467-018-07162-5"
],
"effect_size_source_sentence": "Furthermore, unitary IPSCs recorded at IS3-OLM synapses had a small amplitude and low release probability but summated efficiently during high-frequency firing of IS3 interneurons."
}- source_refs
[
"paper:paper-6b0c417962ed"
]
- source_span
We found that type 3 IS (IS3) cells that coexpress the vasoactive intestinal polypeptide (VIP) and calretinin contact several distinct types of interneurons within the hippocampal CA1 stratum oriens/alveus (O/A), with preferential innervation of oriens-lacunosum moleculare cells (OLMs) through dendritic synapses. In contrast, VIP-positive basket cells provided perisomatic inhibition to CA1 pyramidal neurons with the...
- evidence_refs
[
{
"ref": "paper:paper-6b0c417962ed"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}