Version history

{
  "scope": "mouse hippocampus CA1; ex vivo paired-patch + optogenetics",
  "claim_text": "In hippocampal CA1, VIP+/calretinin+ interneuron-specific type 3 (IS3) cells preferentially innervate oriens-lacunosum moleculare (OLM) interneurons through dendritic synapses with small unitary IPSCs (low Pr) that summate during high-frequency firing; VIP+ basket cells (not IS3) provide asynchronous perisomatic inhibition to pyramidal neurons but do not contact O/A interneurons — establishing distinct VIP subclasses with non-overlapping post-synaptic targeting.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.3813-13.2014",
    "claim": "In hippocampal CA1, VIP+/calretinin+ interneuron-specific type 3 (IS3) cells preferentially innervate oriens-lacunosum moleculare (OLM) interneurons through dendritic synapses with small unitary IPSCs (low Pr) that summate during high-frequency firing; VIP+ basket cells (not IS3) provide asynchronous perisomatic inhibition to pyramidal neurons but do not contact O/A interneurons — establishing distinct VIP subclasses with non-overlapping post-synaptic targeting.",
    "title": null,
    "cite_key": "Tyan2014",
    "evidence": "Dual simultaneous paired patch-clamp recordings + targeted optogenetic stimulation in acute mouse hippocampal slices.",
    "effect_size": "IS3→OLM synapses: small amplitude, low Pr, efficient summation at high frequencies.",
    "text_access": "fulltext",
    "study_system": "mouse hippocampus CA1; ex vivo paired-patch + optogenetics",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "replicates",
    "_source_cluster_index": 39,
    "claim_source_sentence": "We found that type 3 IS (IS3) cells that coexpress the vasoactive intestinal polypeptide (VIP) and calretinin contact several distinct types of interneurons within the hippocampal CA1 stratum oriens/alveus (O/A), with preferential innervation of oriens-lacunosum moleculare cells (OLMs) through dendritic synapses. In contrast, VIP-positive basket cells provided perisomatic inhibition to CA1 pyramidal neurons with the asynchronous GABA release and were not connected with O/A interneurons.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2019.01.009",
      "10.1038/s41467-018-07162-5"
    ],
    "effect_size_source_sentence": "Furthermore, unitary IPSCs recorded at IS3-OLM synapses had a small amplitude and low release probability but summated efficiently during high-frequency firing of IS3 interneurons."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "IS3→OLM synapses: small amplitude, low Pr, efficient summation at high frequencies.",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-6b0c417962ed"
  ],
  "source_span": "We found that type 3 IS (IS3) cells that coexpress the vasoactive intestinal polypeptide (VIP) and calretinin contact several distinct types of interneurons within the hippocampal CA1 stratum oriens/alveus (O/A), with preferential innervation of oriens-lacunosum moleculare cells (OLMs) through dendritic synapses. In contrast, VIP-positive basket cells provided perisomatic inhibition to CA1 pyramidal neurons with the...",
  "study_system": "mouse hippocampus CA1; ex vivo paired-patch + optogenetics",
  "evidence_refs": [
    {
      "ref": "paper:paper-6b0c417962ed"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Dual simultaneous paired patch-clamp recordings + targeted optogenetic stimulation in acute mouse hippocampal slices.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicates",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}