Version history

{
  "scope": "D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving",
  "claim_text": "Optogenetic activation of indirect-pathway D2-MSNs produced a parkinsonian state with bradykinesia and freezing while direct-pathway activation increased locomotion, providing the first direct experimental support for opposing pathway functions.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature09159",
    "claim": "Optogenetic activation of indirect-pathway D2-MSNs produced a parkinsonian state with bradykinesia and freezing while direct-pathway activation increased locomotion, providing the first direct experimental support for opposing pathway functions.",
    "cite_key": "Kravitz2010",
    "evidence": "",
    "effect_size": "indirect-pathway activation: increased freezing, bradykinesia, decreased locomotor initiations",
    "text_access": "fulltext",
    "study_system": "D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving",
    "source_cluster_id": "cluster_04",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "During illumination, D1-ChR2 mice initiated more frequent ambulatory bouts (n=9, p<0.005), and these bouts lasted longer (n=9, p<0.05); no changes in ambulation velocity occurred (n=9, p=0.21).",
    "replication_evidence_dois": [
      "10.1038/nn.3100",
      "10.1016/j.cell.2016.06.032",
      "10.1038/nature17639",
      "10.1016/j.neuron.2016.06.010"
    ],
    "effect_size_source_sentence": "Bilateral excitation of indirect-pathway MSNs elicited a parkinsonian state, distinguished by increased freezing, bradykinesia and decreased locomotor initiations."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "indirect-pathway activation: increased freezing, bradykinesia, decreased locomotor initiations",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:5c30e0b5-d627-4661-b656-d88df1b47830"
  ],
  "source_span": "During illumination, D1-ChR2 mice initiated more frequent ambulatory bouts (n=9, p<0.005), and these bouts lasted longer (n=9, p<0.05); no changes in ambulation velocity occurred (n=9, p=0.21).",
  "study_system": "D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving",
  "evidence_refs": [
    {
      "ref": "paper:5c30e0b5-d627-4661-b656-d88df1b47830"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}