Details
- scope
- D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- effect_size
- indirect-pathway activation: increased freezing, bradykinesia, decreased locomotor initiations
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-04
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- During illumination, D1-ChR2 mice initiated more frequent ambulatory bouts (n=9, p<0.005), and these bouts lasted longer (n=9, p<0.05); no changes in ambulation velocity occurred (n=9, p=0.21).
- study_system
- D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving
- section_title
- Striatal Output Pathways: Direct, Indirect, and Beyond
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-04
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
Optogenetic activation of indirect-pathway D2-MSNs produced a parkinsonian state with bradykinesia and freezing while direct-pathway activation increased locomotion, providing the first direct experimental support for opposing pathway functions.
- raw_fields
{ "n": 0, "doi": "10.1038/nature09159", "claim": "Optogenetic activation of indirect-pathway D2-MSNs produced a parkinsonian state with bradykinesia and freezing while direct-pathway activation increased locomotion, providing the first direct experimental support for opposing pathway functions.", "cite_key": "Kravitz2010", "evidence": "", "effect_size": "indirect-pathway activation: increased freezing, bradykinesia, decreased locomotor initiations", "text_access": "fulltext", "study_system": "D1-Cre and D2-Cre BAC transgenic mice, channelrhodopsin-2 in dorsal striatum, freely-moving", "source_cluster_id": "cluster_04", "replication_status": "independently_replicated", "claim_source_sentence": "During illumination, D1-ChR2 mice initiated more frequent ambulatory bouts (n=9, p<0.005), and these bouts lasted longer (n=9, p<0.05); no changes in ambulation velocity occurred (n=9, p=0.21).", "replication_evidence_dois": [ "10.1038/nn.3100", "10.1016/j.cell.2016.06.032", "10.1038/nature17639", "10.1016/j.neuron.2016.06.010" ], "effect_size_source_sentence": "Bilateral excitation of indirect-pathway MSNs elicited a parkinsonian state, distinguished by increased freezing, bradykinesia and decreased locomotor initiations." }- source_refs
[ "paper:5c30e0b5-d627-4661-b656-d88df1b47830" ]
- evidence_refs
[ { "ref": "paper:5c30e0b5-d627-4661-b656-d88df1b47830" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }