Version history

{
  "scope": "review of rat cortex in vitro (Kawaguchi 1997)",
  "claim_text": "VIP+ bipolar cells are *depolarized by muscarinic agonists* in cortex, in addition to nicotinic and serotonergic depolarization — placing the VIP class under multi-modal cholinergic neuromodulation (both fast nicotinic and slow muscarinic), although the muscarinic effect has not been extensively quantified.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2016.06.033",
    "claim": "VIP+ bipolar cells are *depolarized by muscarinic agonists* in cortex, in addition to nicotinic and serotonergic depolarization — placing the VIP class under multi-modal cholinergic neuromodulation (both fast nicotinic and slow muscarinic), although the muscarinic effect has not been extensively quantified.",
    "title": null,
    "cite_key": "Tremblay2016",
    "evidence": "review citing Kawaguchi 1997 (Tremblay 2016)",
    "effect_size": "qualitative — muscarinic depolarization in VIP bipolar cells",
    "text_access": "fulltext",
    "study_system": "review of rat cortex in vitro (Kawaguchi 1997)",
    "_source_cluster": "cluster_04_intrinsic_electrophysiology",
    "replication_status": "replication_unknown",
    "_source_cluster_index": 92,
    "claim_source_sentence": "It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists (Kawaguchi, 1997), however this has not been extensively studied.",
    "replication_evidence_dois": [
      "10.3389/fncir.2020.00032"
    ],
    "effect_size_source_sentence": "It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "effect_size": "qualitative — muscarinic depolarization in VIP bipolar cells",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-53c8505de50f"
  ],
  "source_span": "It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists (Kawaguchi, 1997), however this has not been extensively studied.",
  "study_system": "review of rat cortex in vitro (Kawaguchi 1997)",
  "evidence_refs": [
    {
      "ref": "paper:paper-53c8505de50f"
    }
  ],
  "section_title": "Intrinsic Electrophysiology",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "review citing Kawaguchi 1997 (Tremblay 2016)",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-05-electrophysiology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}