- claim_text
VIP+ bipolar cells are *depolarized by muscarinic agonists* in cortex, in addition to nicotinic and serotonergic depolarization — placing the VIP class under multi-modal cholinergic neuromodulation (both fast nicotinic and slow muscarinic), although the muscarinic effect has not been extensively quantified.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2016.06.033",
"claim": "VIP+ bipolar cells are *depolarized by muscarinic agonists* in cortex, in addition to nicotinic and serotonergic depolarization — placing the VIP class under multi-modal cholinergic neuromodulation (both fast nicotinic and slow muscarinic), although the muscarinic effect has not been extensively quantified.",
"title": null,
"cite_key": "Tremblay2016",
"evidence": "review citing Kawaguchi 1997 (Tremblay 2016)",
"effect_size": "qualitative — muscarinic depolarization in VIP bipolar cells",
"text_access": "fulltext",
"study_system": "review of rat cortex in vitro (Kawaguchi 1997)",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replication_unknown",
"_source_cluster_index": 92,
"claim_source_sentence": "It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists (Kawaguchi, 1997), however this has not been extensively studied.",
"replication_evidence_dois": [
"10.3389/fncir.2020.00032"
],
"effect_size_source_sentence": "It has been reported that Vip-expressing bipolar neurons are also depolarized by muscarinic agonists."
}- source_refs
[
"paper:paper-53c8505de50f"
]
- evidence_refs
[
{
"ref": "paper:paper-53c8505de50f"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}