Version history

{
  "scope": "D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)",
  "claim_text": "Synchronized over-activation of striatal D1+ medium spiny neurons is causally linked to levodopa-induced dyskinesia in PD model rats.",
  "raw_fields": {
    "n": 0,
    "doi": "10.3389/fnagi.2022.783893",
    "claim": "Synchronized over-activation of striatal D1+ medium spiny neurons is causally linked to levodopa-induced dyskinesia in PD model rats.",
    "cite_key": "Gao2022b",
    "evidence": "Fiber photometry of GCaMP6 in D1-Cre rats during levodopa-induced dyskinesia; optogenetic and chemogenetic deactivation suppressed dyskinesia.",
    "effect_size": "n = 8",
    "text_access": "fulltext",
    "study_system": "D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)",
    "source_cluster_id": "cluster_13",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "In addition,\nwe found that CNO injection significantly reduced the dyskinetic\nbehavior of hM4Di-expressing LID rats in the early phase.",
    "replication_evidence_dois": [
      "10.3390/life16030506",
      "10.1002/advs.202513670"
    ],
    "effect_size_source_sentence": "(G) Power (at 0.2–7 Hz over 5 min) obtained from GCaMP fluorescence traces (dF/F) of normal, non-LID and LID rats (n = 8 for each group,\nKruskal–Wallis one way analysis of variance on ranks with post-hoc Student–Newman–Keuls Method: H2 = 12.560, P = 0.002; LID vs. non-LID: q = 5.000; LID vs.\nnormal: q = 4.159; Normal vs. non-LID: q = 3.267; *P < 0.05, **P < 0.01)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": "n = 8",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-cc6dd7ced1e7"
  ],
  "source_span": "In addition, we found that CNO injection significantly reduced the dyskinetic behavior of hM4Di-expressing LID rats in the early phase.",
  "study_system": "D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)",
  "evidence_refs": [
    {
      "ref": "paper:paper-cc6dd7ced1e7"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Fiber photometry of GCaMP6 in D1-Cre rats during levodopa-induced dyskinesia; optogenetic and chemogenetic deactivation suppressed dyskinesia.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}