Details
- scope
- D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)
- claim_text
- Synchronized over-activation of striatal D1+ medium spiny neurons is causally linked to levodopa-induced dyskinesia in PD model rats.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- effect_size
- n = 8
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- In addition, we found that CNO injection significantly reduced the dyskinetic behavior of hM4Di-expressing LID rats in the early phase.
- study_system
- D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Fiber photometry of GCaMP6 in D1-Cre rats during levodopa-induced dyskinesia; optogenetic and chemogenetic deactivation suppressed dyskinesia.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.3389/fnagi.2022.783893", "claim": "Synchronized over-activation of striatal D1+ medium spiny neurons is causally linked to levodopa-induced dyskinesia in PD model rats.", "cite_key": "Gao2022b", "evidence": "Fiber photometry of GCaMP6 in D1-Cre rats during levodopa-induced dyskinesia; optogenetic and chemogenetic deactivation suppressed dyskinesia.", "effect_size": "n = 8", "text_access": "fulltext", "study_system": "D1-Cre rat 6-OHDA model with chronic levodopa exposure (LID)", "source_cluster_id": "cluster_13", "replication_status": "independently_replicated", "claim_source_sentence": "In addition,\nwe found that CNO injection significantly reduced the dyskinetic\nbehavior of hM4Di-expressing LID rats in the early phase.", "replication_evidence_dois": [ "10.3390/life16030506", "10.1002/advs.202513670" ], "effect_size_source_sentence": "(G) Power (at 0.2–7 Hz over 5 min) obtained from GCaMP fluorescence traces (dF/F) of normal, non-LID and LID rats (n = 8 for each group,\nKruskal–Wallis one way analysis of variance on ranks with post-hoc Student–Newman–Keuls Method: H2 = 12.560, P = 0.002; LID vs. non-LID: q = 5.000; LID vs.\nnormal: q = 4.159; Normal vs. non-LID: q = 3.267; *P < 0.05, **P < 0.01)." }- source_refs
[ "paper:paper-cc6dd7ced1e7" ]
- evidence_refs
[ { "ref": "paper:paper-cc6dd7ced1e7" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }