Version history

{
  "scope": "rat cortex",
  "claim_text": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
  "raw_fields": {
    "n": 31,
    "doi": "10.1016/j.celrep.2025.116792",
    "claim": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
    "evidence": "The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 corticothalamic neurons (L6CThNs), ultimately exhibits a marked preference for synapsing onto par",
    "effect_size": "Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; F",
    "text_access": "fulltext",
    "study_system": "rat cortex",
    "replication_status": "within_lab_replicated",
    "claim_source_sentence": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; Figures 5D and 5E ), correlating with the period of L6 U CThN axon elaboration in L4 between P10–P11 "
  },
  "section_id": "section_06_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "effect_size": "Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; F",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-d8c260dd6b59"
  ],
  "source_span": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
  "study_system": "rat cortex",
  "evidence_refs": [
    {
      "ref": "paper:paper-d8c260dd6b59"
    }
  ],
  "section_title": "Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 corticothalamic neurons (L6CThNs), ultimately exhibits a marked preference for synapsing onto par",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "within_lab_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}