We show that the intracortical axons of L6CThNs develop in phases, first elonga…

{
  "n": 31,
  "doi": "10.1016/j.celrep.2025.116792",
  "claim": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
  "evidence": "The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 corticothalamic neurons (L6CThNs), ultimately exhibits a marked preference for synapsing onto par",
  "effect_size": "Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; F",
  "text_access": "fulltext",
  "study_system": "rat cortex",
  "replication_status": "within_lab_replicated",
  "claim_source_sentence": "We show that the intracortical axons of L6CThNs develop in phases, first elongating within L6, then pausing before extending translaminar branches into L4.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; Figures 5D and 5E ), correlating with the period of L6 U CThN axon elaboration in L4 between P10–P11 "
}

Although using a different approach, our ChR2-circuit mapping suggested a later increase in the number and/or the strength of L6CThN→L4PV synapses; L4PV responses were significantly larger at P14–P15 (9.3 ± 2.2 mV, mean ± SEM) than at P10–P11 (1.81 ± 0.90 mV; p < 0.0004, Wilcoxon rank-sum test; F

[
  "paper:paper-d8c260dd6b59"
]

[
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    "ref": "paper:paper-d8c260dd6b59"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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The function of the mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 corticothalamic neurons (L6CThNs), ultimately exhibits a marked preference for synapsing onto par