Version history

{
  "scope": "mean-field whole-cortex model + EEG",
  "claim_text": "Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-induced loss of consciousness as failure of feedback predictive routing through VIP-disinhibitory gating.",
  "raw_fields": {
    "n": null,
    "id": "cluster_11_finding_87",
    "doi": "10.1073/pnas.2315160121",
    "pmid": "39374396",
    "year": "2024",
    "claim": "Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-induced loss of consciousness as failure of feedback predictive routing through VIP-disinhibitory gating.",
    "pmcid": "PMC11494327",
    "title": "Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.",
    "authors": "Xiong YS, Donoghue JA, Lundqvist M, Mahnke M, Major AJ, Brown EN, Miller EK, Bastos AM.",
    "journal": "Proceedings of the National Academy of Sciences of the United States of America",
    "cite_key": "Xiong2024",
    "evidence": "Coupled cortical regions modeled with cell-class-specific GABA-A; anesthesia simulated via potentiation of GABA shifts predictive flow.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "mean-field whole-cortex model + EEG",
    "_source_cluster": "cluster_11_computational_models",
    "replication_status": "replicated_independent",
    "_source_cluster_index": 86,
    "claim_source_sentence": "This led to a disinhibition of gamma/spiking, consistent with the predictive routing model.",
    "replication_evidence_dois": [
      "10.7554/elife.55130",
      "10.1523/jneurosci.1369-21.2021",
      "10.1038/s41598-017-01830-0",
      "10.1371/journal.pcbi.1013306",
      "10.1016/j.neuron.2021.11.016"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_13",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "source_kind": "review_finding",
  "source_path": "evidence/section_13_evidence_package.json",
  "source_refs": [
    "paper:paper-ef4c763cc63c"
  ],
  "source_span": "This led to a disinhibition of gamma/spiking, consistent with the predictive routing model.",
  "study_system": "mean-field whole-cortex model + EEG",
  "evidence_refs": [
    {
      "ref": "paper:paper-ef4c763cc63c"
    }
  ],
  "section_title": "Synthesis and Conclusion: Reassessing the Canonical VIP Disinhibitor",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Coupled cortical regions modeled with cell-class-specific GABA-A; anesthesia simulated via potentiation of GABA shifts predictive flow.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated_independent",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-13-conclusion",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_13_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}