Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-in…

{
  "n": null,
  "id": "cluster_11_finding_87",
  "doi": "10.1073/pnas.2315160121",
  "pmid": "39374396",
  "year": "2024",
  "claim": "Mean-field whole-cortex model with PV/SST/VIP interneurons explains propofol-induced loss of consciousness as failure of feedback predictive routing through VIP-disinhibitory gating.",
  "pmcid": "PMC11494327",
  "title": "Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.",
  "authors": "Xiong YS, Donoghue JA, Lundqvist M, Mahnke M, Major AJ, Brown EN, Miller EK, Bastos AM.",
  "journal": "Proceedings of the National Academy of Sciences of the United States of America",
  "cite_key": "Xiong2024",
  "evidence": "Coupled cortical regions modeled with cell-class-specific GABA-A; anesthesia simulated via potentiation of GABA shifts predictive flow.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mean-field whole-cortex model + EEG",
  "_source_cluster": "cluster_11_computational_models",
  "replication_status": "replicated_independent",
  "_source_cluster_index": 86,
  "claim_source_sentence": "This led to a disinhibition of gamma/spiking, consistent with the predictive routing model.",
  "replication_evidence_dois": [
    "10.7554/elife.55130",
    "10.1523/jneurosci.1369-21.2021",
    "10.1038/s41598-017-01830-0",
    "10.1371/journal.pcbi.1013306",
    "10.1016/j.neuron.2021.11.016"
  ],
  "effect_size_source_sentence": null
}

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]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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