Version history

{
  "scope": "mouse V1+HVAs in vivo + EM connectomics (MICrONS)",
  "claim_text": "In the MICrONS functional connectomics volume of awake mouse V1 plus higher visual areas (VISrl, VISal, VISlm), pairing dense calcium imaging of ~75,000 neurons with electron-microscopy synaptic reconstruction shows that 'like-to-like' connectivity between functionally similar excitatory neurons generalizes across cortical layers and across visual areas.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/s41586-025-08790-w",
    "claim": "In the MICrONS functional connectomics volume of awake mouse V1 plus higher visual areas (VISrl, VISal, VISlm), pairing dense calcium imaging of ~75,000 neurons with electron-microscopy synaptic reconstruction shows that 'like-to-like' connectivity between functionally similar excitatory neurons generalizes across cortical layers and across visual areas.",
    "cite_key": "TheMICrONSConsortium2025",
    "evidence": "Two-photon calcium imaging of ~75,000 neurons in mouse V1 and HVAs co-registered to a millimeter-scale serial-section EM volume reconstructed with >200,000 cells and 0.5 billion synapses; proofreading of identified axonal/dendritic arbors for excitatory subpopulations.",
    "effect_size": "Like-to-like connectivity principle replicated across layers and across V1, AL, RL, LM",
    "text_access": "fulltext",
    "study_system": "mouse V1+HVAs in vivo + EM connectomics (MICrONS)",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The combination of structural connectivity and functional similarity across thousands of pairs of individual neurons enabled a new examination of ‘like-to-like’ connectivity and shows that this principle generalizes across cortical layers and visual areas.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1038/nature14182",
      "10.1038/nature09880",
      "10.1038/s41586-025-08840-3"
    ],
    "effect_size_source_sentence": "These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Like-to-like connectivity principle replicated across layers and across V1, AL, RL, LM",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-aecac0566e4a"
  ],
  "source_span": "The combination of structural connectivity and functional similarity across thousands of pairs of individual neurons enabled a new examination of ‘like-to-like’ connectivity and shows that this principle generalizes across cortical layers and visual areas.",
  "study_system": "mouse V1+HVAs in vivo + EM connectomics (MICrONS)",
  "evidence_refs": [
    {
      "ref": "paper:paper-aecac0566e4a"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon calcium imaging of ~75,000 neurons in mouse V1 and HVAs co-registered to a millimeter-scale serial-section EM volume reconstructed with >200,000 cells and 0.5 billion synapses; proofreading of identified axonal/dendritic arbors for excitatory subpopulations.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}