- claim_text
In the MICrONS functional connectomics volume of awake mouse V1 plus higher visual areas (VISrl, VISal, VISlm), pairing dense calcium imaging of ~75,000 neurons with electron-microscopy synaptic reconstruction shows that 'like-to-like' connectivity between functionally similar excitatory neurons generalizes across cortical layers and across visual areas.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41586-025-08790-w",
"claim": "In the MICrONS functional connectomics volume of awake mouse V1 plus higher visual areas (VISrl, VISal, VISlm), pairing dense calcium imaging of ~75,000 neurons with electron-microscopy synaptic reconstruction shows that 'like-to-like' connectivity between functionally similar excitatory neurons generalizes across cortical layers and across visual areas.",
"cite_key": "TheMICrONSConsortium2025",
"evidence": "Two-photon calcium imaging of ~75,000 neurons in mouse V1 and HVAs co-registered to a millimeter-scale serial-section EM volume reconstructed with >200,000 cells and 0.5 billion synapses; proofreading of identified axonal/dendritic arbors for excitatory subpopulations.",
"effect_size": "Like-to-like connectivity principle replicated across layers and across V1, AL, RL, LM",
"text_access": "fulltext",
"study_system": "mouse V1+HVAs in vivo + EM connectomics (MICrONS)",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "The combination of structural connectivity and functional similarity across thousands of pairs of individual neurons enabled a new examination of ‘like-to-like’ connectivity and shows that this principle generalizes across cortical layers and visual areas.",
"source_provenance_status": "ok",
"replication_evidence_dois": [
"10.1038/nature14182",
"10.1038/nature09880",
"10.1038/s41586-025-08840-3"
],
"effect_size_source_sentence": "These data are co-registered with an electron microscopy reconstruction containing more than 200,000 cells and 0.5 billion synapses."
}- source_refs
[
"paper:paper-aecac0566e4a"
]
- source_span
The combination of structural connectivity and functional similarity across thousands of pairs of individual neurons enabled a new examination of ‘like-to-like’ connectivity and shows that this principle generalizes across cortical layers and visual areas.
- evidence_refs
[
{
"ref": "paper:paper-aecac0566e4a"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Two-photon calcium imaging of ~75,000 neurons in mouse V1 and HVAs co-registered to a millimeter-scale serial-section EM volume reconstructed with >200,000 cells and 0.5 billion synapses; proofreading of identified axonal/dendritic arbors for excitatory subpopulations.