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- Live5/17/2026, 4:35:28 PM
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{ "scope": "mouse posterior parietal cortex; two-photon calcium imaging in a delayed match-to-sample task with trial-by-trial decoding of neural drift", "claim_text": "Two-photon calcium imaging in mouse posterior parietal cortex during a delayed match-to-sample task identifies a subset of PPC neurons with joint directional and temporal selectivity; short-term memory errors are not driven by misencoding during the sample phase but by drift of PPC neural activity during the delay — a gradual divergence from the correct representation that predicts incorrect choices — direct evidence that drifting attractor-like persistent activity governs memory accuracy.", "raw_fields": { "n": 0, "doi": "10.1371/journal.pbio.3003359", "claim": "Two-photon calcium imaging in mouse posterior parietal cortex during a delayed match-to-sample task identifies a subset of PPC neurons with joint directional and temporal selectivity; short-term memory errors are not driven by misencoding during the sample phase but by drift of PPC neural activity during the delay — a gradual divergence from the correct representation that predicts incorrect choices — direct evidence that drifting attractor-like persistent activity governs memory accuracy.", "cite_key": "Choi2025c", "evidence": "This drift leads to a gradual divergence away from the correct representation, ultimately leading to incorrect behavioral responses. These results emphasize the importance of maintaining stable neural representations in the PPC for accurate STM.", "effect_size": "", "text_access": "abstract_only", "study_system": "mouse posterior parietal cortex; two-photon calcium imaging in a delayed match-to-sample task with trial-by-trial decoding of neural drift", "argument_role": "supporting", "replication_status": "single_lab", "claim_source_sentence": "Our findings reveal that these errors are more strongly associated with a drift in neural activity during the delay period.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": null }, "section_id": "section_10", "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json", "effect_size": "", "review_repo": "ComputationalReviewRecurrence", "section_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity", "source_kind": "review_finding", "source_path": "evidence/section_10_evidence_package.json", "source_refs": [ "paper:paper-8a77f46a9951" ], "source_span": "Our findings reveal that these errors are more strongly associated with a drift in neural activity during the delay period.", "study_system": "mouse posterior parietal cortex; two-photon calcium imaging in a delayed match-to-sample task with trial-by-trial decoding of neural drift", "evidence_refs": [ { "ref": "paper:paper-8a77f46a9951" } ], "section_title": "10. Physiological signature II — persistent activity and attractor dynamics supported by E→E recurrence (delay-period activity in mouse PFC/ALM, working memory, head-direction)", "source_policy": { "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }, "evidence_summary": "This drift leads to a gradual divergence away from the correct representation, ultimately leading to incorrect behavioral responses. These results emphasize the importance of maintaining stable neural representations in the PPC for accurate STM.", "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9", "replication_status": "single_lab", "review_package_ref": "analysis_bundle:ab-d9c479db9be9", "source_artifact_ref": "wiki_page:computationalreviewrecurrence-10-persistent-activity", "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_10_evidence_package.json", "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "created_by": "persona-jerome-lecoq-gbo-neuroscience", "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }