- claim_text
Administering an allosteric modulator of Kv3.1 channels after the critical period rescues circuit dynamics and tactile defensiveness in Fmr1 KO mice modeling Fragile X Syndrome, demonstrating therapeutic potential of targeting PV-IN ion channels.
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2023.06.009",
"claim": "Administering an allosteric modulator of Kv3.1 channels after the critical period rescues circuit dynamics and tactile defensiveness in Fmr1 KO mice modeling Fragile X Syndrome, demonstrating therapeutic potential of targeting PV-IN ion channels.",
"evidence": "All-optical in vivo approaches showed PV-INs are hypoactive and transiently decoupled from excitatory neurons in postnatal Fmr1 KO mouse somatosensory cortex.",
"effect_size": "rescue of circuit dynamics and tactile defensiveness by Kv3.1 modulation post-critical period",
"text_access": "fulltext",
"study_system": "mouse somatosensory cortex, Fmr1 KO Fragile X model",
"replication_status": "replication_unknown",
"claim_source_sentence": "Critically, administering an allosteric modulator of Kv3.1 channels after the S1 critical period does rescue circuit dynamics and tactile defensiveness.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "administering an allosteric modulator of Kv3.1 channels after the S1 critical period does rescue circuit dynamics and tactile defensiveness."
}- source_refs
[
"paper:paper-dbde38011715"
]
- evidence_refs
[
{
"ref": "paper:paper-dbde38011715"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}