Version history

{
  "scope": "mouse somatosensory cortex, Fmr1 KO Fragile X model",
  "claim_text": "Administering an allosteric modulator of Kv3.1 channels after the critical period rescues circuit dynamics and tactile defensiveness in Fmr1 KO mice modeling Fragile X Syndrome, demonstrating therapeutic potential of targeting PV-IN ion channels.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.neuron.2023.06.009",
    "claim": "Administering an allosteric modulator of Kv3.1 channels after the critical period rescues circuit dynamics and tactile defensiveness in Fmr1 KO mice modeling Fragile X Syndrome, demonstrating therapeutic potential of targeting PV-IN ion channels.",
    "evidence": "All-optical in vivo approaches showed PV-INs are hypoactive and transiently decoupled from excitatory neurons in postnatal Fmr1 KO mouse somatosensory cortex.",
    "effect_size": "rescue of circuit dynamics and tactile defensiveness by Kv3.1 modulation post-critical period",
    "text_access": "fulltext",
    "study_system": "mouse somatosensory cortex, Fmr1 KO Fragile X model",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Critically, administering an allosteric modulator of Kv3.1 channels after the S1 critical period does rescue circuit dynamics and tactile defensiveness.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "administering an allosteric modulator of Kv3.1 channels after the S1 critical period does rescue circuit dynamics and tactile defensiveness."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "rescue of circuit dynamics and tactile defensiveness by Kv3.1 modulation post-critical period",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-dbde38011715"
  ],
  "source_span": "Critically, administering an allosteric modulator of Kv3.1 channels after the S1 critical period does rescue circuit dynamics and tactile defensiveness.",
  "study_system": "mouse somatosensory cortex, Fmr1 KO Fragile X model",
  "evidence_refs": [
    {
      "ref": "paper:paper-dbde38011715"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "All-optical in vivo approaches showed PV-INs are hypoactive and transiently decoupled from excitatory neurons in postnatal Fmr1 KO mouse somatosensory cortex.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}