In mouse V1, top-down feedback projections create a second receptive field outs…

In mouse V1, top-down feedback projections create a second receptive field outside the classical feedforward RF; PV and VIP interneurons (but not SST) respond robustly to inverse stimuli, suggesting VIP recruitment by feedback projections drives the disinhibitory mechanism that creates the feedback RF.

{
  "n": null,
  "doi": "10.1038/s41586-020-2319-4",
  "claim": "In mouse V1, top-down feedback projections create a second receptive field outside the classical feedforward RF; PV and VIP interneurons (but not SST) respond robustly to inverse stimuli, suggesting VIP recruitment by feedback projections drives the disinhibitory mechanism that creates the feedback RF.",
  "title": null,
  "cite_key": "Keller2020b",
  "evidence": "Two-photon Ca2+ imaging of L2/3 excitatory and Gad2/PV/VIP/SOM interneurons in mouse V1 with optogenetic feedback manipulation.",
  "effect_size": "VIP and PV cells robustly respond to inverse stimuli; SOM cells do not — consistent with VIP-mediated disinhibition driving feedback RF.",
  "text_access": "fulltext",
  "study_system": "mouse V1; in vivo two-photon",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "single-study",
  "_source_cluster_index": 28,
  "claim_source_sentence": "Furthermore, both PV and VIP neurons responded to inverse stimuli centered on their ffRF ( , ) and showed size-tuning functions to inverse stimuli that peaked well above their response to the largest classical stimuli.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We hypothesize that SOM inhibitory neurons, which, in contrast to PV and VIP neurons, respond poorly to inverse stimuli while robustly responding to large stimuli covering both fbRFs and ffRFs, could mediate the mutual antagonism consistent with their role in surround suppression ."
}

[
  "paper:paper-e69f1cba3510"
]

[
  {
    "ref": "paper:paper-e69f1cba3510"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}