In mouse primary visual cortex, top-down feedback projections from higher visua…

In mouse primary visual cortex, top-down feedback projections from higher visual areas generate a second, larger non-classical receptive field on V1 excitatory neurons via L5 apical-tuft input — providing direct evidence that cortico-cortical feedback contributes a defined extra-classical RF rather than merely modulating ffRF.

{
  "n": null,
  "doi": "10.1038/s41586-020-2319-4",
  "claim": "In mouse primary visual cortex, top-down feedback projections from higher visual areas generate a second, larger non-classical receptive field on V1 excitatory neurons via L5 apical-tuft input — providing direct evidence that cortico-cortical feedback contributes a defined extra-classical RF rather than merely modulating ffRF.",
  "cite_key": "Keller2020b",
  "evidence": "Two-photon optogenetic and pharmacological manipulation of higher-area feedback projections + V1 cell-attached recording; surround stimulus testing.",
  "effect_size": "Feedback projections to V1 generate a distinct second (extraclassical) receptive field on excitatory neurons.",
  "text_access": "abstract_only",
  "study_system": "Mouse V1; feedback-axon manipulation + RF measurement.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "we show that feedback projections onto excitatory neurons in the mouse primary visual cortex generate a second receptive field that is driven by stimuli outside the ffRF.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Here we show that feedback projections onto excitatory neurons in the mouse primary visual cortex generate a second receptive field that is driven by stimuli outside the ffRF."
}

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