Drivers and modulators differ functionally: drivers transmit receptive-field pr…

{
  "n": 0,
  "doi": "10.1073/pnas.95.12.7121",
  "claim": "Drivers and modulators differ functionally: drivers transmit receptive-field properties via fast ionotropic synapses with sharp cross-correlogram peaks, while modulators alter transmission and often act through metabotropic receptors.",
  "cite_key": "Sherman1998",
  "evidence": "Conceptual analysis of the LGN relay synaptic data extending the driver/modulator distinction to wider thalamic and brain circuits.",
  "effect_size": "Few drivers, many modulators per relay cell; ionotropic drivers vs metabotropic modulators",
  "text_access": "abstract_only",
  "study_system": "visual thalamic relay (review)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We suggest the following distinctions: Cross-correlograms from driver inputs have sharper peaks than those from modulators; there are likely to be few drivers but many modulators for any one cell; and drivers are likely to act only through ionotropic receptors having a fast postsynaptic effect whereas modulators also are likely to activate metabotropic receptors having a slow and prolonged postsynaptic effect.",
  "replication_evidence_dois": [
    "10.1098/rstb.2002.1161",
    "10.1038/nn.4269",
    "10.1016/s0896-6273(01)00582-7"
  ],
  "effect_size_source_sentence": "there are likely to be few drivers but many modulators for any one cell"
}

[
  "paper:paper-903cd8b7ef76"
]

We suggest the following distinctions: Cross-correlograms from driver inputs have sharper peaks than those from modulators; there are likely to be few drivers but many modulators for any one cell; and drivers are likely to act only through ionotropic receptors having a fast postsynaptic effect whereas modulators also are likely to activate metabotropic receptors having a slow and prolonged postsynaptic effect.

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