Version history

{
  "scope": "visual thalamic relay (review)",
  "claim_text": "Drivers and modulators differ functionally: drivers transmit receptive-field properties via fast ionotropic synapses with sharp cross-correlogram peaks, while modulators alter transmission and often act through metabotropic receptors.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1073/pnas.95.12.7121",
    "claim": "Drivers and modulators differ functionally: drivers transmit receptive-field properties via fast ionotropic synapses with sharp cross-correlogram peaks, while modulators alter transmission and often act through metabotropic receptors.",
    "cite_key": "Sherman1998",
    "evidence": "Conceptual analysis of the LGN relay synaptic data extending the driver/modulator distinction to wider thalamic and brain circuits.",
    "effect_size": "Few drivers, many modulators per relay cell; ionotropic drivers vs metabotropic modulators",
    "text_access": "abstract_only",
    "study_system": "visual thalamic relay (review)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We suggest the following distinctions: Cross-correlograms from driver inputs have sharper peaks than those from modulators; there are likely to be few drivers but many modulators for any one cell; and drivers are likely to act only through ionotropic receptors having a fast postsynaptic effect whereas modulators also are likely to activate metabotropic receptors having a slow and prolonged postsynaptic effect.",
    "replication_evidence_dois": [
      "10.1098/rstb.2002.1161",
      "10.1038/nn.4269",
      "10.1016/s0896-6273(01)00582-7"
    ],
    "effect_size_source_sentence": "there are likely to be few drivers but many modulators for any one cell"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "Few drivers, many modulators per relay cell; ionotropic drivers vs metabotropic modulators",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-903cd8b7ef76"
  ],
  "source_span": "We suggest the following distinctions: Cross-correlograms from driver inputs have sharper peaks than those from modulators; there are likely to be few drivers but many modulators for any one cell; and drivers are likely to act only through ionotropic receptors having a fast postsynaptic effect whereas modulators also are likely to activate metabotropic receptors having a slow and prolonged postsynaptic effect.",
  "study_system": "visual thalamic relay (review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-903cd8b7ef76"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Conceptual analysis of the LGN relay synaptic data extending the driver/modulator distinction to wider thalamic and brain circuits.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}