Version history

{
  "scope": "mouse vibrissal motor cortex (vM1); sCRACM with multiple cortical and thalamic source areas",
  "claim_text": "In mouse vibrissal M1, long-range and local excitatory inputs to pyramidal neurons are organized in a layer-specific manner, with orbital cortex targeting L6, secondary motor cortex targeting L5B (including PT neurons), motor thalamus engaging L2/3 through L5B but avoiding L6, and sensory-related thalamic and S1 inputs preferentially targeting upper layers.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.4338-12.2013",
    "claim": "In mouse vibrissal M1, long-range and local excitatory inputs to pyramidal neurons are organized in a layer-specific manner, with orbital cortex targeting L6, secondary motor cortex targeting L5B (including PT neurons), motor thalamus engaging L2/3 through L5B but avoiding L6, and sensory-related thalamic and S1 inputs preferentially targeting upper layers.",
    "cite_key": "Hooks2013",
    "evidence": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) of multiple long-range sources onto pyramidal neurons in mouse vM1.",
    "effect_size": "Source-by-layer specificity (sCRACM input maps).",
    "text_access": "abstract_only",
    "study_system": "mouse vibrissal motor cortex (vM1); sCRACM with multiple cortical and thalamic source areas",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL (ventral anterior thalamic nucleus/ventrolateral thalamic nucleus), targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm (posterior thalamic nuclear group), targeted neurons only in the upper layers (L2/3 and L5A), similar to inputs from somatosensory (barrel) cortex.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Source-by-layer specificity (sCRACM input maps).",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
  ],
  "source_span": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL (ventral anterior thalamic nucleus/ventrolateral thalamic nucleus), targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior s...",
  "study_system": "mouse vibrissal motor cortex (vM1); sCRACM with multiple cortical and thalamic source areas",
  "evidence_refs": [
    {
      "ref": "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) of multiple long-range sources onto pyramidal neurons in mouse vM1.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}