In mouse vibrissal M1, long-range and local excitatory inputs to pyramidal neur…

In mouse vibrissal M1, long-range and local excitatory inputs to pyramidal neurons are organized in a layer-specific manner, with orbital cortex targeting L6, secondary motor cortex targeting L5B (including PT neurons), motor thalamus engaging L2/3 through L5B but avoiding L6, and sensory-related thalamic and S1 inputs preferentially targeting upper layers.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4338-12.2013",
  "claim": "In mouse vibrissal M1, long-range and local excitatory inputs to pyramidal neurons are organized in a layer-specific manner, with orbital cortex targeting L6, secondary motor cortex targeting L5B (including PT neurons), motor thalamus engaging L2/3 through L5B but avoiding L6, and sensory-related thalamic and S1 inputs preferentially targeting upper layers.",
  "cite_key": "Hooks2013",
  "evidence": "Channelrhodopsin-2-assisted circuit mapping (sCRACM) of multiple long-range sources onto pyramidal neurons in mouse vM1.",
  "effect_size": "Source-by-layer specificity (sCRACM input maps).",
  "text_access": "abstract_only",
  "study_system": "mouse vibrissal motor cortex (vM1); sCRACM with multiple cortical and thalamic source areas",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL (ventral anterior thalamic nucleus/ventrolateral thalamic nucleus), targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior sensory-related thalamic areas, including POm (posterior thalamic nuclear group), targeted neurons only in the upper layers (L2/3 and L5A), similar to inputs from somatosensory (barrel) cortex.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
]

Specifically, orbital cortex (OC) inputs primarily targeted neurons in L6. Secondary motor cortex (M2) inputs excited neurons mainly in L5B, including pyramidal tract neurons. In contrast, thalamocortical inputs from anterior motor-related thalamic regions, including VA/VL (ventral anterior thalamic nucleus/ventrolateral thalamic nucleus), targeted neurons in L2/3 through L5B, but avoided L6. Inputs from posterior s...

[
  {
    "ref": "paper:fc06108f-75bb-4dd7-9d5e-3b006f8c4156"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}