Version history

{
  "scope": "adult mouse V1, in vivo optogenetic Cg→V1 axon activation + recordings in V1 + behavioral visual-discrimination task; SST-Cre and VIP-Cre lines",
  "claim_text": "Top-down projections from mouse cingulate (Cg) frontal cortex powerfully modulate V1 sensory processing — optogenetic Cg activation enhances V1 responses and improves visual discrimination, and focal Cg-axon stimulation in V1 produces center facilitation with surround suppression via distinct VIP and SST interneuron motifs.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1126/science.1254126",
    "claim": "Top-down projections from mouse cingulate (Cg) frontal cortex powerfully modulate V1 sensory processing — optogenetic Cg activation enhances V1 responses and improves visual discrimination, and focal Cg-axon stimulation in V1 produces center facilitation with surround suppression via distinct VIP and SST interneuron motifs.",
    "cite_key": "Zhang2014",
    "evidence": "Mouse Cg → V1 long-range corticocortical projection mapped optogenetically; behavioral visual discrimination; SST-Cre and VIP-Cre × halorhodopsin/ChR2 dissection of inhibitory subtype contributions.",
    "effect_size": "Improvement in psychometric visual-discrimination performance; center-facilitation, surround-suppression dissociation by interneuron subtype.",
    "text_access": "abstract_only",
    "study_system": "adult mouse V1, in vivo optogenetic Cg→V1 axon activation + recordings in V1 + behavioral visual-discrimination task; SST-Cre and VIP-Cre lines",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation).",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1126/science.abj5861"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "Improvement in psychometric visual-discrimination performance; center-facilitation, surround-suppression dissociation by interneuron subtype.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-05bd6c97da43"
  ],
  "source_span": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation).",
  "study_system": "adult mouse V1, in vivo optogenetic Cg→V1 axon activation + recordings in V1 + behavioral visual-discrimination task; SST-Cre and VIP-Cre lines",
  "evidence_refs": [
    {
      "ref": "paper:paper-05bd6c97da43"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Mouse Cg → V1 long-range corticocortical projection mapped optogenetically; behavioral visual discrimination; SST-Cre and VIP-Cre × halorhodopsin/ChR2 dissection of inhibitory subtype contributions.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}