- claim_text
Top-down projections from mouse cingulate (Cg) frontal cortex powerfully modulate V1 sensory processing — optogenetic Cg activation enhances V1 responses and improves visual discrimination, and focal Cg-axon stimulation in V1 produces center facilitation with surround suppression via distinct VIP and SST interneuron motifs.
- raw_fields
{
"n": 0,
"doi": "10.1126/science.1254126",
"claim": "Top-down projections from mouse cingulate (Cg) frontal cortex powerfully modulate V1 sensory processing — optogenetic Cg activation enhances V1 responses and improves visual discrimination, and focal Cg-axon stimulation in V1 produces center facilitation with surround suppression via distinct VIP and SST interneuron motifs.",
"cite_key": "Zhang2014",
"evidence": "Mouse Cg → V1 long-range corticocortical projection mapped optogenetically; behavioral visual discrimination; SST-Cre and VIP-Cre × halorhodopsin/ChR2 dissection of inhibitory subtype contributions.",
"effect_size": "Improvement in psychometric visual-discrimination performance; center-facilitation, surround-suppression dissociation by interneuron subtype.",
"text_access": "abstract_only",
"study_system": "adult mouse V1, in vivo optogenetic Cg→V1 axon activation + recordings in V1 + behavioral visual-discrimination task; SST-Cre and VIP-Cre lines",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation).",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [
"10.1126/science.abj5861"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-05bd6c97da43"
]
- source_span
Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation).
- evidence_refs
[
{
"ref": "paper:paper-05bd6c97da43"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}