Version history

{
  "scope": "Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation",
  "claim_text": "Optogenetic stimulation of excitatory cells in mouse V1 produces a salt-and-pepper pattern of distributed suppression among non-stimulated neurons, with ~44% of neurons suppressed; this is quantitatively reproduced by a strongly coupled recurrent E-I network model.",
  "raw_fields": {
    "n": 3,
    "doi": "10.1016/j.neuron.2023.09.010",
    "claim": "Optogenetic stimulation of excitatory cells in mouse V1 produces a salt-and-pepper pattern of distributed suppression among non-stimulated neurons, with ~44% of neurons suppressed; this is quantitatively reproduced by a strongly coupled recurrent E-I network model.",
    "cite_key": "ORawe2023",
    "evidence": "Two-photon optogenetic stimulation of large groups of L2/3 excitatory cells while measuring others with two-photon imaging and electrophysiology; salt-and-pepper of suppressed/excited cells; matches randomly-connected recurrent network model.",
    "effect_size": "proportion suppressed 44%±7% (two-photon) and 38%±8% (electrophysiology); excitatory population mean Δ rate 14.54 spk/s",
    "text_access": "fulltext",
    "study_system": "Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation",
    "argument_role": "supporting",
    "replication_status": "within_lab",
    "claim_source_sentence": "First, we find that stimulation of excitatory cells leads to a salt-and-pepper pattern of local suppression, consistent with the pattern of excited and suppressed cells produced when animals see a strong visual stimulus.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "However, the large fraction of suppressed neurons (,–; proportion suppressed 44%±7%, N=3 animals, mean±standard error) implies it is not that a group of inhibitory neurons was suppressed by stimulation, but that many excitatory neurons were suppressed."
  },
  "section_id": "section_09",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "effect_size": "proportion suppressed 44%±7% (two-photon) and 38%±8% (electrophysiology); excitatory population mean Δ rate 14.54 spk/s",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "source_kind": "review_finding",
  "source_path": "evidence/section_09_evidence_package.json",
  "source_refs": [
    "paper:paper-72cedfe6cf90"
  ],
  "source_span": "First, we find that stimulation of excitatory cells leads to a salt-and-pepper pattern of local suppression, consistent with the pattern of excited and suppressed cells produced when animals see a strong visual stimulus.",
  "study_system": "Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation",
  "evidence_refs": [
    {
      "ref": "paper:paper-72cedfe6cf90"
    }
  ],
  "section_title": "9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon optogenetic stimulation of large groups of L2/3 excitatory cells while measuring others with two-photon imaging and electrophysiology; salt-and-pepper of suppressed/excited cells; matches randomly-connected recurrent network model.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "within_lab",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-09-amplification-isn",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}