Details
- scope
- Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation
- section_id
- section_09
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- effect_size
- proportion suppressed 44%±7% (two-photon) and 38%±8% (electrophysiology); excitatory population mean Δ rate 14.54 spk/s
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- First, we find that stimulation of excitatory cells leads to a salt-and-pepper pattern of local suppression, consistent with the pattern of excited and suppressed cells produced when animals see a strong visual stimulus.
- study_system
- Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation
- section_title
- 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- within_lab
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (6)
- claim_text
Optogenetic stimulation of excitatory cells in mouse V1 produces a salt-and-pepper pattern of distributed suppression among non-stimulated neurons, with ~44% of neurons suppressed; this is quantitatively reproduced by a strongly coupled recurrent E-I network model.
- raw_fields
{ "n": 3, "doi": "10.1016/j.neuron.2023.09.010", "claim": "Optogenetic stimulation of excitatory cells in mouse V1 produces a salt-and-pepper pattern of distributed suppression among non-stimulated neurons, with ~44% of neurons suppressed; this is quantitatively reproduced by a strongly coupled recurrent E-I network model.", "cite_key": "ORawe2023", "evidence": "Two-photon optogenetic stimulation of large groups of L2/3 excitatory cells while measuring others with two-photon imaging and electrophysiology; salt-and-pepper of suppressed/excited cells; matches randomly-connected recurrent network model.", "effect_size": "proportion suppressed 44%±7% (two-photon) and 38%±8% (electrophysiology); excitatory population mean Δ rate 14.54 spk/s", "text_access": "fulltext", "study_system": "Mouse V1 L2/3, awake, two-photon imaging + extracellular recording with optogenetic excitatory stimulation", "argument_role": "supporting", "replication_status": "within_lab", "claim_source_sentence": "First, we find that stimulation of excitatory cells leads to a salt-and-pepper pattern of local suppression, consistent with the pattern of excited and suppressed cells produced when animals see a strong visual stimulus.", "source_provenance_status": "ok", "replication_evidence_dois": [], "effect_size_source_sentence": "However, the large fraction of suppressed neurons (,–; proportion suppressed 44%±7%, N=3 animals, mean±standard error) implies it is not that a group of inhibitory neurons was suppressed by stimulation, but that many excitatory neurons were suppressed." }- source_refs
[ "paper:paper-72cedfe6cf90" ]
- evidence_refs
[ { "ref": "paper:paper-72cedfe6cf90" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }- evidence_summary
Two-photon optogenetic stimulation of large groups of L2/3 excitatory cells while measuring others with two-photon imaging and electrophysiology; salt-and-pepper of suppressed/excited cells; matches randomly-connected recurrent network model.