MAPseq reconstruction of 591 mouse V1 projection neurons shows that the majorit…

MAPseq reconstruction of 591 mouse V1 projection neurons shows that the majority of single V1 cells target multiple cortical and subcortical areas in non-random combinations, indicating that V1 broadcasts information to multiple targets via diverse but structured projection sub-classes.

{
  "n": 591,
  "doi": "10.1038/nature26159",
  "claim": "MAPseq reconstruction of 591 mouse V1 projection neurons shows that the majority of single V1 cells target multiple cortical and subcortical areas in non-random combinations, indicating that V1 broadcasts information to multiple targets via diverse but structured projection sub-classes.",
  "cite_key": "Han2018",
  "evidence": "MAPseq barcoded mapping of 591 V1 neurons; targets across ≥18 cortical and subcortical areas; combinatorial pattern analysis.",
  "effect_size": "591 V1 neurons; ≥18 target areas; most neurons multi-target with structured non-random combinations.",
  "text_access": "fulltext",
  "study_system": "Mouse V1; MAPseq + whole-brain fluorescence axonal tracing.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1016/j.cell.2019.09.023"
  ],
  "effect_size_source_sentence": "Here we determine the projection patterns of 591 individual neurons in the mouse primary visual cortex using whole-brain fluorescence-based axonal tracing and high-throughput DNA sequencing of genetically barcoded neurons (MAPseq)."
}

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  "paper:paper-236d0f50c2dd"
]

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  }
]

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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
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