Version history

{
  "scope": "Mouse V1; MAPseq + whole-brain fluorescence axonal tracing.",
  "claim_text": "MAPseq reconstruction of 591 mouse V1 projection neurons shows that the majority of single V1 cells target multiple cortical and subcortical areas in non-random combinations, indicating that V1 broadcasts information to multiple targets via diverse but structured projection sub-classes.",
  "raw_fields": {
    "n": 591,
    "doi": "10.1038/nature26159",
    "claim": "MAPseq reconstruction of 591 mouse V1 projection neurons shows that the majority of single V1 cells target multiple cortical and subcortical areas in non-random combinations, indicating that V1 broadcasts information to multiple targets via diverse but structured projection sub-classes.",
    "cite_key": "Han2018",
    "evidence": "MAPseq barcoded mapping of 591 V1 neurons; targets across ≥18 cortical and subcortical areas; combinatorial pattern analysis.",
    "effect_size": "591 V1 neurons; ≥18 target areas; most neurons multi-target with structured non-random combinations.",
    "text_access": "fulltext",
    "study_system": "Mouse V1; MAPseq + whole-brain fluorescence axonal tracing.",
    "argument_role": "supporting",
    "replication_status": "replicated",
    "claim_source_sentence": "Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1016/j.cell.2019.09.023"
    ],
    "effect_size_source_sentence": "Here we determine the projection patterns of 591 individual neurons in the mouse primary visual cortex using whole-brain fluorescence-based axonal tracing and high-throughput DNA sequencing of genetically barcoded neurons (MAPseq)."
  },
  "section_id": "section_08",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "effect_size": "591 V1 neurons; ≥18 target areas; most neurons multi-target with structured non-random combinations.",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_08_evidence_package.json",
  "source_refs": [
    "paper:paper-236d0f50c2dd"
  ],
  "source_span": "Most neurons targeted multiple cortical areas, often in non-random combinations, suggesting that sub-classes of intracortical projection neurons exist.",
  "study_system": "Mouse V1; MAPseq + whole-brain fluorescence axonal tracing.",
  "evidence_refs": [
    {
      "ref": "paper:paper-236d0f50c2dd"
    }
  ],
  "section_title": "8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "MAPseq barcoded mapping of 591 V1 neurons; targets across ≥18 cortical and subcortical areas; combinatorial pattern analysis.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-08-cross-areal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}