In neonatal mouse barrel cortex, monosynaptic rabies tracing and slice electrop…

In neonatal mouse barrel cortex, monosynaptic rabies tracing and slice electrophysiology show that L2/3 pyramidal neurons receive significant L5 input during the first postnatal week, and silencing L5 outputs disrupts L4→L2/3 connectivity — establishing an inverted developmental L5→L2/3 translaminar dependence.

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  "n": 0,
  "doi": "10.1038/s41467-024-55783-w",
  "claim": "In neonatal mouse barrel cortex, monosynaptic rabies tracing and slice electrophysiology show that L2/3 pyramidal neurons receive significant L5 input during the first postnatal week, and silencing L5 outputs disrupts L4→L2/3 connectivity — establishing an inverted developmental L5→L2/3 translaminar dependence.",
  "cite_key": "VargasOrtiz2025",
  "evidence": "Microprism in vivo 2P imaging + rabies tracing + slice electrophysiology in neonatal mouse barrel cortex.",
  "effect_size": "Significant L5→L2/3 input during P1 week; silencing L5 reduces spontaneous activity and disrupts L4→L2/3 connections.",
  "text_access": "abstract_only",
  "study_system": "neonatal mouse barrel cortex; in vivo 2P + rabies + slice ephys",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Monosynaptic rabies tracing and slice electrophysiology experiments reveal that layer 2/3 pyramidal neurons receive significant layer 5 inputs during the first postnatal week, and silencing layer 5 synaptic outputs results in a significant reduction in spontaneous activity, abnormal sensory-evoked activity and disrupted layer 4-layer 2/3 connectivity.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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Monosynaptic rabies tracing and slice electrophysiology experiments reveal that layer 2/3 pyramidal neurons receive significant layer 5 inputs during the first postnatal week, and silencing layer 5 synaptic outputs results in a significant reduction in spontaneous activity, abnormal sensory-evoked activity and disrupted layer 4-layer 2/3 connectivity.

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