Version history

{
  "scope": "mouse cortex; VIPCre conditional KO + biocytin",
  "claim_text": "Cortical VIP interneurons split into two molecularly and morphologically distinct subtypes during development: a calretinin-expressing (CR+) bipolar subtype and a cholecystokinin-expressing (CCK+) multipolar subtype, regulated by partially separable genetic programs.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.1021-21.2021",
    "claim": "Cortical VIP interneurons split into two molecularly and morphologically distinct subtypes during development: a calretinin-expressing (CR+) bipolar subtype and a cholecystokinin-expressing (CCK+) multipolar subtype, regulated by partially separable genetic programs.",
    "title": null,
    "cite_key": "Stachniak2021",
    "evidence": "VIPCre conditional Prox1 deletion during early postnatal life; immunolabel + morphology + slice electrophysiology in mouse cortex.",
    "effect_size": "CR+ bipolar vs CCK+ multipolar molecular dichotomy",
    "text_access": "fulltext",
    "study_system": "mouse cortex; VIPCre conditional KO + biocytin",
    "_source_cluster": "cluster_03_morphology",
    "replication_status": "replicated",
    "_source_cluster_index": 14,
    "claim_source_sentence": "Prox1 removal during embryonic development impairs VIP cell migration, cell survival, as well as dendritic development and afferent connectivity of the calretinin-expressing (CR+) VIP bipolar subtype (Miyoshi et al., 2015).",
    "replication_evidence_dois": [
      "10.1038/s41586-020-2907-3",
      "10.1016/j.cell.2020.09.057"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "effect_size": "CR+ bipolar vs CCK+ multipolar molecular dichotomy",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-04-morphology",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-b5b2bae45f13"
  ],
  "source_span": "Prox1 removal during embryonic development impairs VIP cell migration, cell survival, as well as dendritic development and afferent connectivity of the calretinin-expressing (CR+) VIP bipolar subtype (Miyoshi et al., 2015).",
  "study_system": "mouse cortex; VIPCre conditional KO + biocytin",
  "evidence_refs": [
    {
      "ref": "paper:paper-b5b2bae45f13"
    }
  ],
  "section_title": "Morphological Diversity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "VIPCre conditional Prox1 deletion during early postnatal life; immunolabel + morphology + slice electrophysiology in mouse cortex.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-04-morphology",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}