Details
- scope
- mouse cortex; VIPCre conditional KO + biocytin
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json
- effect_size
- CR+ bipolar vs CCK+ multipolar molecular dichotomy
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-04-morphology
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- Prox1 removal during embryonic development impairs VIP cell migration, cell survival, as well as dendritic development and afferent connectivity of the calretinin-expressing (CR+) VIP bipolar subtype (Miyoshi et al., 2015).
- study_system
- mouse cortex; VIPCre conditional KO + biocytin
- section_title
- Morphological Diversity
- evidence_summary
- VIPCre conditional Prox1 deletion during early postnatal life; immunolabel + morphology + slice electrophysiology in mouse cortex.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-04-morphology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_04_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Cortical VIP interneurons split into two molecularly and morphologically distinct subtypes during development: a calretinin-expressing (CR+) bipolar subtype and a cholecystokinin-expressing (CCK+) multipolar subtype, regulated by partially separable genetic programs.
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.1021-21.2021", "claim": "Cortical VIP interneurons split into two molecularly and morphologically distinct subtypes during development: a calretinin-expressing (CR+) bipolar subtype and a cholecystokinin-expressing (CCK+) multipolar subtype, regulated by partially separable genetic programs.", "title": null, "cite_key": "Stachniak2021", "evidence": "VIPCre conditional Prox1 deletion during early postnatal life; immunolabel + morphology + slice electrophysiology in mouse cortex.", "effect_size": "CR+ bipolar vs CCK+ multipolar molecular dichotomy", "text_access": "fulltext", "study_system": "mouse cortex; VIPCre conditional KO + biocytin", "_source_cluster": "cluster_03_morphology", "replication_status": "replicated", "_source_cluster_index": 14, "claim_source_sentence": "Prox1 removal during embryonic development impairs VIP cell migration, cell survival, as well as dendritic development and afferent connectivity of the calretinin-expressing (CR+) VIP bipolar subtype (Miyoshi et al., 2015).", "replication_evidence_dois": [ "10.1038/s41586-020-2907-3", "10.1016/j.cell.2020.09.057" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-b5b2bae45f13" ]
- evidence_refs
[ { "ref": "paper:paper-b5b2bae45f13" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }