Details
- scope
- rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- effect_size
- ~67% prototypic vs ~27% arkypallidal; arkypallidal target striatum but not STN
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-04
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN).
- study_system
- rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification
- section_title
- Striatal Output Pathways: Direct, Indirect, and Beyond
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-04
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.4662-14.2015", "claim": "In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.", "cite_key": "Abdi2015", "evidence": "", "effect_size": "~67% prototypic vs ~27% arkypallidal; arkypallidal target striatum but not STN", "text_access": "abstract_only", "study_system": "rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification", "source_cluster_id": "cluster_04", "replication_status": "replicated", "claim_source_sentence": "Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN).", "replication_evidence_dois": [ "10.1016/j.neuron.2012.04.027", "10.1523/jneurosci.4672-14.2015", "10.1016/j.neuron.2015.03.007" ], "effect_size_source_sentence": "In contrast, arkypallidal neurons expressed the transcription factor FoxP2, constituted just over one-fourth of GPe neurons, and innervated the striatum but not STN." }- source_refs
[ "paper:paper-83df86143d80" ]
- evidence_refs
[ { "ref": "paper:paper-83df86143d80" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }