In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of…

In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4662-14.2015",
  "claim": "In dopamine-intact rats, prototypic Nkx2-1/Lhx6 GPe neurons constitute ~67% of GPe and innervate STN, while FoxP2+ arkypallidal neurons constitute ~27% and innervate striatum but not STN, confirming the dichotomy in the absence of pathology.",
  "cite_key": "Abdi2015",
  "evidence": "",
  "effect_size": "~67% prototypic vs ~27% arkypallidal; arkypallidal target striatum but not STN",
  "text_access": "abstract_only",
  "study_system": "rat, dopamine-intact GPe, juxtacellular recording with molecular and circuit identification",
  "source_cluster_id": "cluster_04",
  "replication_status": "replicated",
  "claim_source_sentence": "Prototypic neurons coexpressed the transcription factors Nkx2-1 and Lhx6, comprised approximately two-thirds of all GPe neurons, and were the major GPe cell type innervating the subthalamic nucleus (STN).",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2012.04.027",
    "10.1523/jneurosci.4672-14.2015",
    "10.1016/j.neuron.2015.03.007"
  ],
  "effect_size_source_sentence": "In contrast, arkypallidal neurons expressed the transcription factor FoxP2, constituted just over one-fourth of GPe neurons, and innervated the striatum but not STN."
}

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