Version history

{
  "scope": "mouse (BARseq in auditory cortex)",
  "claim_text": "BARseq, an in-situ-sequencing-based barcoded projection mapping technique, mapped the projections of 3,579 spatially resolved neurons in mouse auditory cortex to 11 areas, confirming laminar segregation of IT, PT-like, and CT projection classes and revealing a projection type restricted almost exclusively to transcriptionally defined IT subtypes.",
  "raw_fields": {
    "n": 3579,
    "doi": "10.1016/j.cell.2019.09.023",
    "claim": "BARseq, an in-situ-sequencing-based barcoded projection mapping technique, mapped the projections of 3,579 spatially resolved neurons in mouse auditory cortex to 11 areas, confirming laminar segregation of IT, PT-like, and CT projection classes and revealing a projection type restricted almost exclusively to transcriptionally defined IT subtypes.",
    "cite_key": "Chen2019",
    "evidence": "In-situ sequencing of RNA barcodes injected via Sindbis virus to read out single-neuron projection patterns combined with gene-expression readout in mouse auditory cortex.",
    "effect_size": "3,579 neurons; 11 target areas; 3 major projection classes (IT, PT-like, CT)",
    "text_access": "fulltext",
    "study_system": "mouse (BARseq in auditory cortex)",
    "source_cluster_id": "cluster_03",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Consistent with the fact that PT-l but not CT neurons project to the striatum, only 8 / 250 (3.2%) putative CT neurons sequenced in situ projected to the caudal striatum, whereas 59 / 245 (24%) putative PT-l neurons sequenced in situ projected to the caudal striatum.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Mapping the projections to 11 areas of 3,579 neurons in mouse auditory cortex using BARseq confirmed the laminar organization of the three top classes (intratelencephalic [IT], pyramidal tract-like [PT-like], and corticothalamic [CT]) of projection neurons."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "effect_size": "3,579 neurons; 11 target areas; 3 major projection classes (IT, PT-like, CT)",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-03",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-1bafe87bf289"
  ],
  "source_span": "Consistent with the fact that PT-l but not CT neurons project to the striatum, only 8 / 250 (3.2%) putative CT neurons sequenced in situ projected to the caudal striatum, whereas 59 / 245 (24%) putative PT-l neurons sequenced in situ projected to the caudal striatum.",
  "study_system": "mouse (BARseq in auditory cortex)",
  "evidence_refs": [
    {
      "ref": "paper:paper-1bafe87bf289"
    }
  ],
  "section_title": "The Cortico-Striatal Interface: Topography, Cell Types, and Input Convergence",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "In-situ sequencing of RNA barcodes injected via Sindbis virus to read out single-neuron projection patterns combined with gene-expression readout in mouse auditory cortex.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-03",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_03_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}