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"n": "",
"doi": "10.1016/j.neuroscience.2014.07.070",
"claim": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.",
"title": null,
"cite_key": "Yu2014",
"evidence": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.. 5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, we show that deletion of the 5-HT3AR gene in transgenic mice abolished N-methyl-d-aspartate (NMDA) receptor (NMDAR)-dependent long-term depression (LTD) induced by low-frequency stimulation (L",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "cortex (mouse)",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "single",
"_source_cluster_index": 113,
"claim_source_sentence": null,
"replication_evidence_dois": []
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5-HT3A receptors are required in long-term depression and AMPA receptor internalization.. 5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, we show that deletion of the 5-HT3AR gene in transgenic mice abolished N-methyl-d-aspartate (NMDA) receptor (NMDAR)-dependent long-term depression (LTD) induced by low-frequency stimulation (L