Version history

{
  "scope": "cortex (mouse)",
  "claim_text": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.",
  "raw_fields": {
    "n": "",
    "doi": "10.1016/j.neuroscience.2014.07.070",
    "claim": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.",
    "title": null,
    "cite_key": "Yu2014",
    "evidence": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.. 5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, we show that deletion of the 5-HT3AR gene in transgenic mice abolished N-methyl-d-aspartate (NMDA) receptor (NMDAR)-dependent long-term depression (LTD) induced by low-frequency stimulation (L",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "cortex (mouse)",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "single",
    "_source_cluster_index": 113,
    "claim_source_sentence": null,
    "replication_evidence_dois": []
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-3f57975ee3cf"
  ],
  "source_span": "",
  "study_system": "cortex (mouse)",
  "evidence_refs": [
    {
      "ref": "paper:paper-3f57975ee3cf"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "5-HT3A receptors are required in long-term depression and AMPA receptor internalization.. 5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, we show that deletion of the 5-HT3AR gene in transgenic mice abolished N-methyl-d-aspartate (NMDA) receptor (NMDAR)-dependent long-term depression (LTD) induced by low-frequency stimulation (L",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}