Version history

{
  "scope": "mouse cortex, Lhx6 KO with Arx/CXCR7 rescue",
  "claim_text": "In Lhx6−/− mice, some MGE cells aberrantly acquire a CGE-like identity; in vivo complementation shows Lhx6-regulated targets Arx and CXCR7 rescue separable aspects of Lhx6 function — Arx restores SST/PV specification while CXCR7 restores migration/laminar positioning, explaining the molecular basis of MGE versus CGE lineage divergence.",
  "raw_fields": {
    "n": null,
    "doi": "10.1016/j.neuron.2014.02.030",
    "claim": "In Lhx6−/− mice, some MGE cells aberrantly acquire a CGE-like identity; in vivo complementation shows Lhx6-regulated targets Arx and CXCR7 rescue separable aspects of Lhx6 function — Arx restores SST/PV specification while CXCR7 restores migration/laminar positioning, explaining the molecular basis of MGE versus CGE lineage divergence.",
    "title": null,
    "cite_key": "Vogt2014",
    "evidence": "Abstract: in vivo MGE complementation/transplantation assay, Lhx6 KO mice with Arx and CXCR7 rescue.",
    "effect_size": null,
    "text_access": "abstract_only",
    "study_system": "mouse cortex, Lhx6 KO with Arx/CXCR7 rescue",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single-study",
    "_source_cluster_index": 27,
    "claim_source_sentence": "Here, we demonstrate that some Lhx6⁻/⁻ MGE cells acquire a CGE-like fate.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-09e3387a22aa"
  ],
  "source_span": "Here, we demonstrate that some Lhx6⁻/⁻ MGE cells acquire a CGE-like fate.",
  "study_system": "mouse cortex, Lhx6 KO with Arx/CXCR7 rescue",
  "evidence_refs": [
    {
      "ref": "paper:paper-09e3387a22aa"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Abstract: in vivo MGE complementation/transplantation assay, Lhx6 KO mice with Arx and CXCR7 rescue.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}