In Lhx6−/− mice, some MGE cells aberrantly acquire a CGE-like identity; in vivo…

In Lhx6−/− mice, some MGE cells aberrantly acquire a CGE-like identity; in vivo complementation shows Lhx6-regulated targets Arx and CXCR7 rescue separable aspects of Lhx6 function — Arx restores SST/PV specification while CXCR7 restores migration/laminar positioning, explaining the molecular basis of MGE versus CGE lineage divergence.

{
  "n": null,
  "doi": "10.1016/j.neuron.2014.02.030",
  "claim": "In Lhx6−/− mice, some MGE cells aberrantly acquire a CGE-like identity; in vivo complementation shows Lhx6-regulated targets Arx and CXCR7 rescue separable aspects of Lhx6 function — Arx restores SST/PV specification while CXCR7 restores migration/laminar positioning, explaining the molecular basis of MGE versus CGE lineage divergence.",
  "title": null,
  "cite_key": "Vogt2014",
  "evidence": "Abstract: in vivo MGE complementation/transplantation assay, Lhx6 KO mice with Arx and CXCR7 rescue.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse cortex, Lhx6 KO with Arx/CXCR7 rescue",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single-study",
  "_source_cluster_index": 27,
  "claim_source_sentence": "Here, we demonstrate that some Lhx6⁻/⁻ MGE cells acquire a CGE-like fate.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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