Indirect-pathway D2-receptor activation drives both L-DOPA dyskinesia and D2-ag…

{
  "n": 0,
  "doi": "10.1002/mds.70299",
  "claim": "Indirect-pathway D2-receptor activation drives both L-DOPA dyskinesia and D2-agonist dystonia, providing genetic evidence that D2 signaling on iMSNs is necessary for these motor symptoms.",
  "cite_key": "Andreoli2026",
  "evidence": "Indirect Striatal Projection Neurons Drive a D2 Receptor-Dependent Pathway to Dyskinesia and Dystonia.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse",
  "source_cluster_id": "cluster_04",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "This effect was inhibited in both knockout models.ConclusionsWe provide experimental evidence that indirect-pathway D2 receptors significantly contribute to the expression of dyskinesia during L-DOPA treatment and mediate D2 agonist-dependent dystonic features. © 2026 The Author(s).",
  "replication_evidence_dois": [
    "10.3389/fnins.2021.614412",
    "10.1016/j.celrep.2018.05.059",
    "10.1016/j.isci.2022.105263"
  ],
  "effect_size_source_sentence": null
}

[
  "paper:paper-930888ab59a2"
]

This effect was inhibited in both knockout models.ConclusionsWe provide experimental evidence that indirect-pathway D2 receptors significantly contribute to the expression of dyskinesia during L-DOPA treatment and mediate D2 agonist-dependent dystonic features. © 2026 The Author(s).

[
  {
    "ref": "paper:paper-930888ab59a2"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}