Version history

{
  "scope": "mouse",
  "claim_text": "Indirect-pathway D2-receptor activation drives both L-DOPA dyskinesia and D2-agonist dystonia, providing genetic evidence that D2 signaling on iMSNs is necessary for these motor symptoms.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1002/mds.70299",
    "claim": "Indirect-pathway D2-receptor activation drives both L-DOPA dyskinesia and D2-agonist dystonia, providing genetic evidence that D2 signaling on iMSNs is necessary for these motor symptoms.",
    "cite_key": "Andreoli2026",
    "evidence": "Indirect Striatal Projection Neurons Drive a D2 Receptor-Dependent Pathway to Dyskinesia and Dystonia.",
    "effect_size": "",
    "text_access": "abstract_only",
    "study_system": "mouse",
    "source_cluster_id": "cluster_04",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "This effect was inhibited in both knockout models.ConclusionsWe provide experimental evidence that indirect-pathway D2 receptors significantly contribute to the expression of dyskinesia during L-DOPA treatment and mediate D2 agonist-dependent dystonic features. © 2026 The Author(s).",
    "replication_evidence_dois": [
      "10.3389/fnins.2021.614412",
      "10.1016/j.celrep.2018.05.059",
      "10.1016/j.isci.2022.105263"
    ],
    "effect_size_source_sentence": null
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "effect_size": "",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-04",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-930888ab59a2"
  ],
  "source_span": "This effect was inhibited in both knockout models.ConclusionsWe provide experimental evidence that indirect-pathway D2 receptors significantly contribute to the expression of dyskinesia during L-DOPA treatment and mediate D2 agonist-dependent dystonic features. © 2026 The Author(s).",
  "study_system": "mouse",
  "evidence_refs": [
    {
      "ref": "paper:paper-930888ab59a2"
    }
  ],
  "section_title": "Striatal Output Pathways: Direct, Indirect, and Beyond",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Indirect Striatal Projection Neurons Drive a D2 Receptor-Dependent Pathway to Dyskinesia and Dystonia.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-04",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}