Version history

{
  "scope": "mouse forelimb M1, paired recordings + sCRACM",
  "claim_text": "In mouse motor cortex, paired recordings and optogenetic mapping reveal strong reciprocal connectivity between layer 6 corticothalamic and intratelencephalic neurons but essentially no CT↔PT excitatory connections, with each excitatory pathway accompanied by amplitude-matched disynaptic inhibition.",
  "raw_fields": {
    "n": "mouse M1 slices; sample size not in abstract",
    "doi": "10.1523/jneurosci.4023-14.2015",
    "claim": "In mouse motor cortex, paired recordings and optogenetic mapping reveal strong reciprocal connectivity between layer 6 corticothalamic and intratelencephalic neurons but essentially no CT↔PT excitatory connections, with each excitatory pathway accompanied by amplitude-matched disynaptic inhibition.",
    "cite_key": "Yamawaki2015",
    "evidence": "Paired recordings combined with subcellular ChR2-assisted circuit mapping in mouse M1 slices, applied to CT (Ntsr1), IT, and PT projection-class neurons.",
    "effect_size": "CT↔CT and CT↔IT pathways strong; CT↔PT 'strikingly little'; I/E ratio higher in CT-driven than IT-driven pathways",
    "text_access": "abstract_only",
    "study_system": "mouse forelimb M1, paired recordings + sCRACM",
    "argument_role": "supporting",
    "replication_status": "Consistent with V1/S1 L6 CT excitation of L5 IT and PV interneurons (Crandall 2014; L6CT developmental study 2025)",
    "claim_source_sentence": "Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔CT and CT↔IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔PT excitatory connectivity.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [
      "10.1523/JNEUROSCI.1325-14.2014",
      "10.1016/j.celrep.2025.116792"
    ],
    "effect_size_source_sentence": "There was strikingly little CT↔PT excitatory connectivity. ... CT neurons evoked proportionally more inhibition relative to excitation (I/E ratio) than IT neurons."
  },
  "section_id": "section_04",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "effect_size": "CT↔CT and CT↔IT pathways strong; CT↔PT 'strikingly little'; I/E ratio higher in CT-driven than IT-driven pathways",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "source_kind": "review_finding",
  "source_path": "evidence/section_04_evidence_package.json",
  "source_refs": [
    "paper:paper-77ff3f69a352"
  ],
  "source_span": "Stimulating and recording from CT, intratelencephalic (IT), and pyramidal tract (PT) projection neurons, we found strong CT↔CT and CT↔IT connections; however, CT→IT connections were limited to IT neurons in layer 6, not 5B. There was strikingly little CT↔PT excitatory connectivity.",
  "study_system": "mouse forelimb M1, paired recordings + sCRACM",
  "evidence_refs": [
    {
      "ref": "paper:paper-77ff3f69a352"
    }
  ],
  "section_title": "4. Translaminar excitatory loops in mouse — L4→L2/3→L5→L6→L4 within the column; asymmetry of forward and backward intracortical projections",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Paired recordings combined with subcellular ChR2-assisted circuit mapping in mouse M1 slices, applied to CT (Ntsr1), IT, and PT projection-class neurons.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "Consistent with V1/S1 L6 CT excitation of L5 IT and PV interneurons (Crandall 2014; L6CT developmental study 2025)",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-04-translaminar",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_04_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}